in vivo IMAGING IN ALIVE ANIMAL
For these studies, we can propose several imaging technologies: PET Scan, Scanner, X-ray, MRI, Bioluminescence. The new technology, PET (Positron Emission Tomography) Scan, by labeling with 18FDG (Fluoro-Deoxy-d-Glucose), allows to observe phenomenon (micro-metastasis formation, drug bio-distribution, etc) in the same alive animal at different time points without sacrificing animals.
Here is a typical illustration for in vivo imaging. A549 tumor cells were orthotopically injected into athymic mice. Mice were monitored twice a week. In vivo imaging was carried out 5 weeks post-tumor cell inoculation. Marker: 18F-fluoro-deoxy-d-glucose (FDG)-hybrid positron emission tomography (PET).